ProjectDescription : we performed a genome-wide linkage scan in a previously unpublished extended family in which dyslexia seems to be transmitted
with an autosomal dominant pattern of inheritance. We identified a locus on chromosome 7q21.11 showing evidence of linkage to the disorder (LOD=2.82). Whole genome sequencing of key individuals enabled the assessment of coding, noncoding and structural variation in the family. Two rare intronic SNPs within the SEMA3C gene, which were predicted to have functional effects, cosegregated with dyslexia
and the risk haplotype on 7q21.11.